Rhea Metformin Hydrochloride Contraindications

Metformin must not be used in the following cases: Known hypersensitivity to metformin hyrdrochloride or to any of the excipients.
Severe destabilization of diabetes with either pre-coma or ketoacidosis (a condition caused by substances called 'ketone bodies' accumulating in the blood; symptoms include stomach pain, fast and deep breathing, sleepiness or unusual fruity odor of the breath.
Renal insufficiency, even if moderate (impairment of kidney function with increased blood creatinine levels or decreased creatinine clearance <60 mL/min).
Acute conditions with the potential to alter renal functions such as: Dehydration due to persistent or severe diarrhea, recurrent vomiting; Severe infection (for example, respiratory tract infection, urinary tract infection); Following an X-ray examination involving the use of iodinated contrast media (for example, intravenous urography, angiography).
Elective major surgery, see Precautions.
Acute or chronic disease which may cause tissue hypoxia such as cardiac failure, recent myocardial infarction, respiratory insufficiency, shock.
Hepatic insufficiency (impaired liver function).
Acute alcohol intoxication, alcoholism (excessive consumption of alcoholic beverages).